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Ammonium Chloride → tert-Butyl 4-hydroxy-3,3-dimethylpiperidine-1-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 反応物 | tert-Butyl 3,3-dimethyl-4-oxopiperidine-1-carboxylate | HCID 22278899 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | tert-Butyl 4-hydroxy-3,3-dimethylpiperidine-1-carboxylate | HCID 53393265 | 96% |
反応手順
To a stirring solution of 1-Boc-3,3-dimethylpiperidin-4-one (0.48 g, 2.1 mmol) in methanol (20 mL) at 0° C., was added sodium borohydride (0.096 g, 2.5 mmol). After 1 h, satd aq ammonium chloride (1 mL) was added and the solution was concentrated in vacuo. The residue was flushed through a pad of silica gel, eluting with ethyl acetate and the filtrate was concentrated in vacuo to give 0.46 g (96%) of a clear colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07700628B2 |
| 出典データセット | uspto-grants-2010_04 |
| ORD ID | ord-ba77462b0e6e43a2ab986ef289811f3d |
| 出典メモ | uspto-grants-2010_04 |