反応式
C(O)(=O)CC(CC(O)=O)(C(O)=O)O.F[C:15]1[CH:39]=[CH:38][C:18]([C:19]([NH:21][C:22]2[CH:37]=[CH:36][CH:35]=[CH:34][C:23]=2[C:24]([NH:26][C:27]2[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][N:28]=2)=[O:25])=[O:20])=[C:17]([O:40][CH:41]2[CH2:46][CH2:45][N:44]([C:47]([O:49][C:50]([CH3:53])([CH3:52])[CH3:51])=[O:48])[CH2:43][CH2:42]2)[CH:16]=1.[OH:54][CH:55]1[CH2:59][CH2:58][NH:57][CH2:56]1>>[C:50]([O:49][C:47]([N:44]1[CH2:45][CH2:46][CH:41]([O:40][C:17]2[CH:16]=[C:15]([N:57]3[CH2:58][CH2:59][CH:55]([OH:54])[CH2:56]3)[CH:39]=[CH:38][C:18]=2[C:19]([NH:21][C:22]2[CH:37]=[CH:36][CH:35]=[CH:34][C:23]=2[C:24]([NH:26][C:27]2[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][N:28]=2)=[O:25])=[O:20])[CH2:42][CH2:43]1)=[O:48])([CH3:52])([CH3:51])[CH3:53]参加物
4
反応物 3
生成物 1
実験手順
Using methods substantially equivalent to those described in example 4-F except that the workup used saturated aqueous citric acid instead of water, 2-[2-(1-tert-butoxy-carbonylpiperidin-4-yloxy)-4-(3-hydroxypyrrolidin-1-yl)benzoylamino]-N-(5-chhloro-pyridin-2-yl)benzamide (160 mg, 0.25 mmol, 47%) was prepared from 2-[4-fluoro-2-(1-tert-butoxycarbonylpiperidin-4-yloxy)benzoylamino]-N-(5-chloropyridin-2-yl)-benzamide and 3-hydroxypyrrolidine.
出典と根拠
- ORDレコード
- ord-27403cb47eba47ee8edd45aeb0687867
- 出典データセット
- uspto-grants-2010_04
- 特許番号
- US07700628B2
関連ノート
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