1H,2H,2AH,3H,4H,8BH-Naphtho[1,2-B]azet-2-one → methyl rac-(1S,2S)-1-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylate hydrochloride

HRID 64419ノート

反応式

HRID 64419 の反応式
[NH:1]1[C:4](=[O:5])[CH:3]2[CH2:6][CH2:7][C:8]3[C:13]([CH:2]12)=[CH:12][CH:11]=[CH:10][CH:9]=3.[ClH:14].[CH3:15][OH:16]>>[ClH:14].[NH2:1][CH:2]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7][CH2:6][CH:3]1[C:4]([O:16][CH3:15])=[O:5]

参加物

3

反応物 2

HCID 3002861H,2H,2AH,3H,4H,8BH-Naphtho[1,2-B]azet-2-oneHCID 21893726Hydrochloride methanol

生成物 1

HCID 86713429methyl rac-(1S,2S)-1-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylate hydrochloride

反応条件

温度
90 °C

実験手順

To 2.36 g of 2a,3,4,8b-tetrahydronaphtho[1,2-b]azet-2(1H)-one was added 50 ml of a 10% hydrogen chloride/methanol solution, followed by stirring at 90° C. for 6 hours. After leaving to be cooled, the solvent was evaporated under reduced pressure. To the obtained residue were added methanol and diethyl ether, and the insoluble material was collected by filtration and dried to obtain 3.08 g of methyl rac-(1S,2S)-1-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylate hydrochloride.

後処理

  1. customAfter leaving
  2. temperatureto be cooled
  3. customthe solvent was evaporated under reduced pressure
  4. additionTo the obtained residue were added methanol and diethyl ether
  5. filtrationthe insoluble material was collected by filtration
  6. customdried

出典と根拠

ORDレコード
ord-8f1e3bd1cf164e369dba1efa3822e546
出典データセット
uspto-grants-2016_09
特許番号
US09447090B2

反応ノート

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