化工社化工社 化学情報印刷レポート · 研究参考用
2-amino-N-(5-chloropyridin-2-yl)benzamide → 2-[4-(B enzyloxy)-2-(1-tert-butoxycarbonylpiperidin-4-yloxy)benzoylamino]-N-(5-chloropyridin-2-yl)benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-amino-N-(5-chloropyridin-2-yl)benzamide | HCID 21906381 | — |
| 反応物 | 4-Benzyloxy-2-(1-tert-butoxycarbonylpiperidin-4-yloxy)benzoic acid | HCID 68535719 | — |
| 生成物 | 2-[4-(B enzyloxy)-2-(1-tert-butoxycarbonylpiperidin-4-yloxy)benzoylamino]-N-(5-chloropyridin-2-yl)benzamide | HCID 68532666 | — |
反応手順
Using methods substantially equivalent to those described in Example 1-F, 4-benzyloxy-2-(1-tert-butoxycarbonylpiperidin-4-yloxy)benzoic acid (529 mg, 1.27 mmol) and N-(5-chloropyridin-2-yl)-2-aminobenzamide (297 mg, 1.20 mmol) afforded, after purification by chromatography (SiO2: EtOAc in hexanes), 493 mg (63%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07700628B2 |
| 出典データセット | uspto-grants-2010_04 |
| ORD ID | ord-b362c472deaa453eac5060bc7a1ee1e1 |
| 出典メモ | uspto-grants-2010_04 |