Methanol → Methyl 4-isopropyl-2-methoxymethoxybenzoate

HRID 644211ノート

反応式

HRID 644211 の反応式
C(Cl)Cl.[CH:4]([C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=[O:12])=[C:9]([O:16][CH2:17][O:18][CH3:19])[CH:8]=1)([CH3:6])[CH3:5].CO.[CH3:22][Si](C=[N+]=[N-])(C)C>CC(O)=O.CCCCCC>[CH:4]([C:7]1[CH:15]=[CH:14][C:10]([C:11]([O:13][CH3:22])=[O:12])=[C:9]([O:16][CH2:17][O:18][CH3:19])[CH:8]=1)([CH3:6])[CH3:5]

参加物

7

反応物 4

HCID 887MethanolHCID 6344DichloromethaneHCID 167693TrimethylsilyldiazomethaneHCID 685322784-Isopropyl-2-methoxymethoxybenzoic acid

生成物 1

HCID 68533886Methyl 4-isopropyl-2-methoxymethoxybenzoate

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 8058Hexane溶媒

実験手順

Into methylene chloride (40 mL) was dissolved 4-isopropyl-2-methoxymethoxy-benzoic acid (6.0 g, 26.8 mmol). Methanol (10 mL) was added, followed by the dropwise addition of 2 M hexane solution of trimethylsilyldiazomethane (14.7 mL). After 2 h, HOAc (0.5 mL) was added and the solvent was removed under vacuum, giving the title compound as an oil, which was used in next step without further purification.

後処理

  1. customthe solvent was removed under vacuum

出典と根拠

ORDレコード
ord-d11ef92e482541bb958da1018f73d6b8
出典データセット
uspto-grants-2010_04
特許番号
US07700628B2

反応ノート

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