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3-Nitropyridin-2-ylamine → 5-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)-benzoylamino]-N-(3-nitropyridin-2-yl)benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Nitropyridin-2-ylamine | HCID 77887 | — |
| 反応物 | 6-Fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)phenyl]-4H-3,1-benzoxazin-4-one | HCID 57860842 | — |
| 反応物 | 5-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]-N-(3-nitro-pyridin-2-yl)benzamide hydrochloride | HCID 68532907 | — |
| 生成物 | 5-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)-benzoylamino]-N-(3-nitropyridin-2-yl)benzamide | HCID 57860841 | — |
反応手順
Using methods substantially equivalent to those described in Example 118, 5-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]-N-(3-nitro-pyridin-2-yl)benzamide hydrochloride was prepared from 6-fluoro-2-[4-(pyrrolidin-1-yl)-2-(1-methylpiperidin-4-yloxy)phenyl]-4H-3,1-benzoxazin-4-one and 2-amino-3-nitro-pyridine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07700628B2 |
| 出典データセット | uspto-grants-2010_04 |
| ORD ID | ord-7ec737d003a04eeca340e52d70ec6f32 |
| 出典メモ | uspto-grants-2010_04 |