Dimethyl Sulfoxide → HCID 68537107、化合物

HRID 644268

反応式

HRID 644268 の反応式
F[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([O:12][CH2:13][O:14][CH3:15])[CH:3]=1.CS(C)=O.[CH2:20]([S-:22])[CH3:21].[Na+]>O>[CH2:20]([S:22][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([O:12][CH2:13][O:14][CH3:15])[CH:3]=1)[CH3:21]

参加物

5

反応物 3

HCID 679Dimethyl SulfoxideHCID 4459711Sodium ethanethiolateHCID 58437341Methyl 4-fluoro-2-(methoxymethoxy)benzoate

生成物 1

HCID 68537107HCID 68537107、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a solution of methyl 4-fluoro-2-(methoxymethoxy)benzoate (10.6 g, 50 mmol) and DMSO (20 mL), under nitrogen, was added sodium ethanethiolate (5.8 g, 55 mmol) in portions. The exothermic reaction was stirred for 19 h, diluted with water, and extracted with ethyl acetate. The organic layer was concentrated; and the residue was dissolved in ether, filtered through diatomaceus earth, and concentrated to give intermediate methyl 4-(ethylthio)-2-(methoxymethoxy)benzoate.

後処理

  1. customThe exothermic reaction
  2. extractionextracted with ethyl acetate
  3. concentrationThe organic layer was concentrated
  4. dissolutionand the residue was dissolved in ether
  5. filtrationfiltered through diatomaceus earth
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-d0e303483cf64d2d85a34241994a09d2
出典データセット
uspto-grants-2010_04
特許番号
US07700628B2

関連ノート

読み込み中…