Water → dimethyl-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-ylmethyl)-amine

HRID 644353ノート

反応式

HRID 644353 の反応式
O.C([O-])([O-])=O.[K+].[K+].[CH3:8][N:9]([CH2:11][C:12]1[CH:28]=[CH:27][C:15]2[CH2:16][CH2:17][N:18](C(=O)C(F)(F)F)[CH2:19][CH2:20][C:14]=2[CH:13]=1)[CH3:10]>CO>[CH3:8][N:9]([CH3:10])[CH2:11][C:12]1[CH:28]=[CH:27][C:15]2[CH2:16][CH2:17][NH:18][CH2:19][CH2:20][C:14]=2[CH:13]=1

参加物

5

反応物 3

HCID 962WaterHCID 11430Potassium CarbonateHCID 866042901-(7-Dimethylaminomethyl-1,2,4,5-tetrahydro-3-benzazepin-3-yl)-2,2,2-trifluoroethanone

生成物 1

HCID 59814517dimethyl-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-ylmethyl)-amine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

50 mL water and 8.5 g (61.51 mmol) K2CO3 were added to a solution of 4.5 g (14.98 mmol) 1-(7-dimethylaminomethyl-1,2,4,5-tetrahydro-3-benzazepin-3-yl)-2,2,2-trifluoroethanone in 50 mL MeOH and the reaction mixture was stirred for 72 h at RT. The reaction solution was evaporated down i.vac., the residue was combined with DCM, filtered to remove insoluble ingredients and evaporated down i.vac. The desired product was obtained in the form of a light-brown oil.

後処理

  1. customThe reaction solution was evaporated down i.vac
  2. filtrationfiltered
  3. customto remove insoluble ingredients
  4. customevaporated down i.vac

出典と根拠

ORDレコード
ord-78f55ee5da4948ada05e808a66cc8273
出典データセット
uspto-grants-2010_04
特許番号
US07700589B2

反応ノート

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