2-indan-5-ylmethyl-4-oxo-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-butanoic acid → methyl (1'-{2-indan-5-ylmethyl-4-oxo-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-butyryl}-[4,4']bipiperidinyl-1-yl)-acetate
反応式
[CH2:1]1[C:9]2[C:4](=[CH:5][C:6]([CH2:10][CH:11]([CH2:15][C:16](=[O:34])[N:17]3[CH2:22][CH2:21][CH:20]([N:23]4[CH2:32][C:31]5[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=5)[NH:25][C:24]4=[O:33])[CH2:19][CH2:18]3)[C:12](O)=[O:13])=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[CH3:35][O:36][C:37](=[O:51])[CH2:38][N:39]1[CH2:44][CH2:43][CH:42]([CH:45]2[CH2:50][CH2:49][NH:48][CH2:47][CH2:46]2)[CH2:41][CH2:40]1>>[CH2:1]1[C:9]2[C:4](=[CH:5][C:6]([CH2:10][CH:11]([CH2:15][C:16](=[O:34])[N:17]3[CH2:18][CH2:19][CH:20]([N:23]4[CH2:32][C:31]5[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=5)[NH:25][C:24]4=[O:33])[CH2:21][CH2:22]3)[C:12]([N:48]3[CH2:49][CH2:50][CH:45]([CH:42]4[CH2:41][CH2:40][N:39]([CH2:38][C:37]([O:36][CH3:35])=[O:51])[CH2:44][CH2:43]4)[CH2:46][CH2:47]3)=[O:13])=[CH:7][CH:8]=2)[CH2:3][CH2:2]1参加物
3
反応物 2
生成物 1
実験手順
Prepared analogously to Example 76e) from and 2-indan-5-ylmethyl-4-oxo-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-butanoic acid and methyl[4,4′]bipiperidinyl-1-yl-acetate.