Benzenamine, 3,5-bis(trifluoromethyl)- → 4-Acetylamino-N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-methoxybenzamide

反応式

[C:1]([NH:4][C:5]1[C:13]([Cl:14])=[CH:12][C:8]([C:9]([OH:11])=O)=[C:7]([O:15][CH3:16])[CH:6]=1)(=[O:3])[CH3:2].[F:17][C:18]([F:31])([F:30])[C:19]1[CH:20]=[C:21]([CH:23]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:25]=1)[NH2:22]>>[C:1]([NH:4][C:5]1[C:13]([Cl:14])=[CH:12][C:8]([C:9]([NH:22][C:21]2[CH:23]=[C:24]([C:26]([F:27])([F:28])[F:29])[CH:25]=[C:19]([C:18]([F:17])([F:30])[F:31])[CH:20]=2)=[O:11])=[C:7]([O:15][CH3:16])[CH:6]=1)(=[O:3])[CH3:2]

参加物

反応物 2

HCID 9480Benzenamine, 3,5-bis(trifluoromethyl)-

HCID 109884964-Acetamido-5-chloro-2-methoxybenzoic acid

生成物 1

HCID 178602074-Acetylamino-N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-methoxybenzamide収率 23.8%

実験手順

Using 4-acetylamino-5-chloro-2-methoxybenzoic acid and 3,5-bis(trifluoromethyl)aniline as the raw materials, the same operation as the Example 24 gave the title compound.

出典と根拠

ORDレコード: ord-7e47afb42dbc4c2988278c18d98d8354
出典データセット: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07700655B2

反応ノート

読み込み中…