化工社化工社 化学情報印刷レポート · 研究参考用
2-(Acetyloxy)-5-chlorobenzoic acid → (S)-5-Chloro-2-hydroxy-N-(3-methyl-1-{[3,5-bis(trifluoromethyl)phenyl]carbamoyl}-butyl)benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(Acetyloxy)-5-chlorobenzoic acid | HCID 2820813 | — |
| 反応物 | (S)-2-Amino-4-methyl-N-[3,5-bis(trifluoromethyl)phenyl]pentanamide | HCID 57459265 | — |
| 生成物 | (S)-5-Chloro-2-hydroxy-N-(3-methyl-1-{[3,5-bis(trifluoromethyl)phenyl]carbamoyl}-butyl)benzamide | HCID 86602738 | 24.8% |
反応手順
Using 2-acetoxy-5-chlorobenzoic acid and (S)-2-amino-4-methyl-N-[3,5-bis-(trifluoromethyl)phenyl]pentanamide as the raw materials, the same operation as the Example 302(2)-(3) gave the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07700655B2 |
| 出典データセット | uspto-grants-2010_04 |
| ORD ID | ord-4fb38d0ad25042fcbf1ec770b22a31cc |
| 出典メモ | uspto-grants-2010_04 |