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Sulfuric acid magnesium salt (1:1) → methyl 3-[(E)-[(S)-tert-butylsulfinyl]iminomethyl]benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| 反応物 | Methyl 3-formylbenzoate | HCID 639145 | — |
| 反応物 | tert-Butylsulfinamide, (S)-(-)- | HCID 11355477 | — |
| 触媒 | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | methyl 3-[(E)-[(S)-tert-butylsulfinyl]iminomethyl]benzoate | HCID 90072367 | 61.4% |
反応手順
A suspension of 3.0 g of methyl 3-formylbenzoate, 2.5 g of (S)-2-methyl-2-propanesulfinamide, 250 mg of pyridinium paratoluene sulfonate, and 11 g of magnesium sulfate in 50 ml of dichloromethane was stirred overnight. The reaction mixture was filtered over Celite and the solvent was then evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography to obtain 3.0 g of methyl 3-[(E)-{[(S)-tert-butylsulfinyl]imino}methyl]benzoate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09447090B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-ae2adc3ef3c44339aeffce4f7d770d98 |
| 出典メモ | uspto-grants-2016_09 |