4,4,4-Trifluoro-1-phenyl-1,3-butanedione → 1-(4-Nitrophenyl)-5-phenyl-3-(trifluoromethyl)pyrazole

反応式

[F:1][C:2]([F:15])([F:14])[C:3](=O)[CH2:4][C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=O.Cl.[N+:17]([C:20]1[CH:25]=[CH:24][C:23]([NH:26][NH2:27])=[CH:22][CH:21]=1)([O-:19])=[O:18]>>[N+:17]([C:20]1[CH:21]=[CH:22][C:23]([N:26]2[C:5]([C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=3)=[CH:4][C:3]([C:2]([F:15])([F:14])[F:1])=[N:27]2)=[CH:24][CH:25]=1)([O-:19])=[O:18]

参加物

反応物 2

HCID 675894,4,4-Trifluoro-1-phenyl-1,3-butanedione

HCID 54634014-Nitrophenylhydrazine hydrochloride

生成物 1

HCID 154987441-(4-Nitrophenyl)-5-phenyl-3-(trifluoromethyl)pyrazole収率 95.2%

実験手順

Using 4,4,4-trifluoro-1-phenyl-1,3-butanedione and 4-nitrophenylhydrazine hydrochloride as the raw materials, the same operation as the Example 538(1) gave the title compound.

出典と根拠

ORDレコード: ord-d1206181a93f4698b82474ce30b369f7
出典データセット: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07700655B2

反応ノート

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