ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Formate → N,N-Diethyl-3-(3-Phenyl-6-trifluoromethyl-3H-benzimidazol-4-yl)propionamide

HRID 644549
ノート
印刷プレビュー

反応式

HRID 644549 の反応式
C([O-])=O.[CH2:4]([N:6]([CH2:30][CH3:31])[C:7](=[O:29])[CH:8]=[CH:9][C:10]1[C:18]2[N:17]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH:16]=[N:15][C:14]=2[CH:13]=[C:12]([C:25]([F:28])([F:27])[F:26])[CH:11]=1)[CH3:5]>C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.[Cl-].[Rh].CS(C)=O>[CH2:30]([N:6]([CH2:4][CH3:5])[C:7](=[O:29])[CH2:8][CH2:9][C:10]1[C:18]2[N:17]([C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH:16]=[N:15][C:14]=2[CH:13]=[C:12]([C:25]([F:27])([F:28])[F:26])[CH:11]=1)[CH3:31]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 2

HCID 283Formate2 回HCID 68679532HCID 68679532、化合物

生成物 1

HCID 68679691N,N-Diethyl-3-(3-Phenyl-6-trifluoromethyl-3H-benzimidazol-4-yl)propionamide

試薬・触媒・溶媒 2

HCID 84599Chlorotris(triphenylphosphine)rhodium(I)触媒HCID 679Dimethyl Sulfoxide溶媒

実験手順

Alumina supported formate was prepared according to the procedure of Danks and Desai (T. N. Danks and B. Desai, Green Chemistry, 2002, 4, 179-180). A Smith Process Vial™ was loaded with alumina supported formate (0.5 g), Wilkinson's catalyst (0.5 mg), N,N-diethyl-3-(3-phenyl-6-trifluoromethyl-3H-benzimidazol-4-yl)acrylamide (0.064 mmol, 25 mg) and dimethylsulphoxide (0.5 ml) and was irradiated for 600 s at 180° C. using a Personal Chemistry Smith Creator™ microwave. The mixture was filtered to remove the solid support and the filtrate was purified by LCMS to give, after evaporation, the title compound as a solid (7.8 mg, 31%), m/z 390.0 (M+H)+.

後処理

  1. customwas prepared
  2. customwas irradiated for 600 s at 180° C.
  3. filtrationThe mixture was filtered
  4. customto remove the solid support
  5. customthe filtrate was purified by LCMS
  6. customto give
  7. customafter evaporation

出典と根拠

ORDレコード
ord-f2302d38c54e4a279d503166b3412e9e
出典データセット
uspto-grants-2010_04
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07700638B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート