化工社化工社 化学情報印刷レポート · 研究参考用
HRID 64459作成日：2026年10月24日
Cyclopentanemethanol → N-[(1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-phenylethyl]-8-(cyclopentylmethoxy)-2-methylimidazo[1,2-a]pyridine-3-carboxamide
https://huagongshe.com/ja/reaction/64459
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Cyclopentanemethanol | HCID 77195 | — |
| 反応物 | Cyanomethylenetributylphosphorane | HCID 4622928 | — |
| 反応物 | N-[(1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-phenylethyl]-8-hydroxy-2-methylimidazo[1,2-a]pyridine-3-carboxamide | HCID 86713409 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | N-[(1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-phenylethyl]-8-(cyclopentylmethoxy)-2-methylimidazo[1,2-a]pyridine-3-carboxamide | HCID 86713474 | — |
反応手順
A mixture of 120 mg of N-[(1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-phenylethyl]-8-hydroxy-2-methylimidazo[1,2-a]pyridine-3-carboxamide, 60 μl of cyclopentylmethanol, 156 μl of (tributylphosphoranylidene)acetonitrile, and 2.4 ml of toluene was stirred at 110° C. for 16 hours, followed by purification using silica gel chromatography, to obtain 100 mg of N-[(1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-phenylethyl]-8-(cyclopentylmethoxy)-2-methylimidazo[1,2-a]pyridine-3-carboxamide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US09447090B2 |
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| 出典データセット | uspto-grants-2016_09 |
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| ORD ID | ord-5ab65197b73f4c0aac187c473560d72d |
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| 出典メモ | uspto-grants-2016_09 |
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