Diphenyl Ether → Ethyl 4-Hydroxy-6,8-dimethyl-1,7-naphthyridine-3-carboxylate

HRID 644811

反応式

HRID 644811 の反応式
C(O[C:4](=[O:21])[C:5](=[CH:11][NH:12][C:13]1[C:14]([CH3:20])=[N:15][C:16]([CH3:19])=[CH:17][CH:18]=1)[C:6]([O:8][CH2:9][CH3:10])=[O:7])C.C1(OC2C=CC=CC=2)C=CC=CC=1>>[CH2:9]([O:8][C:6]([C:5]1[C:4](=[O:21])[C:18]2[C:13](=[C:14]([CH3:20])[N:15]=[C:16]([CH3:19])[CH:17]=2)[NH:12][CH:11]=1)=[O:7])[CH3:10]

参加物

3

反応物 2

HCID 7583Diphenyl EtherHCID 20794345HCID 20794345、化合物

生成物 1

HCID 22397159Ethyl 4-Hydroxy-6,8-dimethyl-1,7-naphthyridine-3-carboxylate収率 36%

反応条件

温度
260 °C

実験手順

2-[(2,6-Dimethyl-pyridin-3-ylamino)-methylene]-malonic acid diethyl ester, prepared in step (i) and diphenyl ether (DPE) were placed in a round bottom flask and this mixture was heated to 260° C. for 1 h. The reaction was then cooled to RT and the content was purified by column chromatography over 100-200 mesh silica gel, eluted with 8% methanol in chloroform, to give the product as a brown solid (36%).

後処理

  1. customwere placed in a round bottom flask
  2. temperatureThe reaction was then cooled to RT
  3. customthe content was purified by column chromatography over 100-200 mesh silica gel
  4. washeluted with 8% methanol in chloroform

出典と根拠

ORDレコード
ord-83842e9080da49b1a6b1fa8d852866f1
出典データセット
uspto-grants-2010_04
特許番号
US07700774B2

関連ノート

読み込み中…