化工社化工社 化学情報印刷レポート · 研究参考用
Tert-butyl 3-benzyl-3,8-diazabicyclo[3.2.1]octane-8-carboxylate → 8-Boc-3,8-diaza-bicyclo(3.2.1)octane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tert-butyl 3-benzyl-3,8-diazabicyclo[3.2.1]octane-8-carboxylate | HCID 15740907 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 8-Boc-3,8-diaza-bicyclo(3.2.1)octane | HCID 15740908 | — |
反応手順
A mixture of 3-benzyl-3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (13.0 g, 43.0 mmol), palladium on carbon (4.0 g, 5%) and ethanol (100 ml, 99%) was stirred under hydrogen. The mixture was filtered on celite, dried and evaporated. A white powder was isolated. Yield 8.4 g (92%). Mp 103.4-106° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07704991B2 |
| 出典データセット | uspto-grants-2010_04 |
| ORD ID | ord-22b8c09f52dd4a4584e4577c0b55a3a0 |
| 出典メモ | uspto-grants-2010_04 |