Hydrochloric Acid → 4-(3,3-Difluoropyrrolidin-1-yl)piperidine hydrochloride

HRID 645475ノート

反応式

HRID 645475 の反応式
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH2:18][CH2:17][C:16]([F:20])([F:19])[CH2:15]2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:21]>O1CCOCC1>[ClH:21].[F:20][C:16]1([F:19])[CH2:17][CH2:18][N:14]([CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH2:15]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 53419023Tert-butyl 4-(3,3-difluoropyrrolidin-1-YL)piperidine-1-carboxylate

生成物 1

HCID 687110244-(3,3-Difluoropyrrolidin-1-yl)piperidine hydrochloride

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

4-(3,3-difluoro-pyrrolidin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester (1.77 mmol) is treated with 4N HCl in 1,4-dioxane (6 mL) and stirred at room temperature for 1 h. The reaction mixture is concentrated in vacuo and the resulting residue is used for the next step without further purification.

後処理

  1. concentrationThe reaction mixture is concentrated in vacuo
  2. customthe resulting residue is used for the next step without further purification

出典と根拠

ORDレコード
ord-a13adcd5765b4148a72afbf3d1f3fbc3
出典データセット
uspto-grants-2010_04
特許番号
US07704996B2

反応ノート

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