HOAt → (r)-2-Cyano-4-(spiro[2.5]oct-6-ylmethyl)pyrimidine-5-carboxylic acid (2-phenyl 1-pyrrolidin-1-ylmethylethyl)amide

HRID 645508

反応式

HRID 645508 の反応式
[C:1]([C:3]1[N:8]=[C:7]([CH2:9][CH:10]2[CH2:17][CH2:16][C:13]3([CH2:15][CH2:14]3)[CH2:12][CH2:11]2)[C:6]([C:18]([OH:20])=O)=[CH:5][N:4]=1)#[N:2].[C:21]1([CH2:27][C@@H:28]([NH2:35])[CH2:29][N:30]2[CH2:34][CH2:33][CH2:32][CH2:31]2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.CCN=C=NCCCN(C)C.Cl.O.C1C=NC2N(O)N=NC=2C=1>CN(C=O)C>[C:21]1([CH2:27][C@@H:28]([NH:35][C:18]([C:6]2[C:7]([CH2:9][CH:10]3[CH2:11][CH2:12][C:13]4([CH2:14][CH2:15]4)[CH2:16][CH2:17]3)=[N:8][C:3]([C:1]#[N:2])=[N:4][CH:5]=2)=[O:20])[CH2:29][N:30]2[CH2:34][CH2:33][CH2:32][CH2:31]2)[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

参加物

6

反応物 4

HCID 181649HOAtHCID 12184138(r)-2-Phenyl-1-pyrrolidin-1-ylmethylethylamineHCID 687032762-Cyano-4-(spiro[2.5]oct-6-ylmethyl)pyrimidine-5-carboxylic acidHCID 87672115EDCl H2O

生成物 1

HCID 91139520(r)-2-Cyano-4-(spiro[2.5]oct-6-ylmethyl)pyrimidine-5-carboxylic acid (2-phenyl 1-pyrrolidin-1-ylmethylethyl)amide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of the crude 2-cyano-4-(spiro[2.5]oct-6-ylmethyl)pyrimidine-5-carboxylic acid (22 mg, step 74.5) in DMF (1.5 mL) are added (R)-2-phenyl-1-pyrrolidin-1-ylmethylethylamine (0.083 mmol), EDCl—H2O (0.11 mmol), and HOAt (0.11 mmol) at room temperature. The reaction mixture is stirred for 24 h and the reaction is quenched by the addition of H2O. The mixture is extracted with AcOEt, and the organic extracts are dried over Na2SO4, filtered, and concentrated in vacuo. The resulting residue is purified by RP-HPLC to give the title compound; MS (M+1)+: 474, Rf (solvent): 0.63 (CH2Cl2:MeOH=10:1).

後処理

  1. customthe reaction is quenched by the addition of H2O
  2. extractionThe mixture is extracted with AcOEt
  3. dry with materialthe organic extracts are dried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo
  6. customThe resulting residue is purified by RP-HPLC

出典と根拠

ORDレコード
ord-ebbaec1b7fa74d20b57f0e984fa021c0
出典データセット
uspto-grants-2010_04
特許番号
US07704996B2

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