Thiourea → Ethyl 5-[[(amino)(imino)methyl]thiomethyl]-1,3-dimethyl-1H-pyrazole-4-carboxylate
反応式
Cl[CH2:2][C:3]1[N:7]([CH3:8])[N:6]=[C:5]([CH3:9])[C:4]=1[C:10]([O:12][CH2:13][CH3:14])=[O:11].[NH2:15][C:16]([NH2:18])=[S:17]>C(O)C>[NH2:18][C:16](=[NH:15])[S:17][CH2:2][C:3]1[N:7]([CH3:8])[N:6]=[C:5]([CH3:9])[C:4]=1[C:10]([O:12][CH2:13][CH3:14])=[O:11]参加物
4
実験手順
A solution under nitrogen was prepared from 10.7 g of the compound produced in Example 1 and 3.95 g of thiourea in 200 ml of ethanol. After refluxing the solution four hours, it was allowed to stir at room temperature overnight. The solvent was removed under reduced pressure. Then, the residue was triturated with hexane to give 16 g of solid (wet weight), m.p. 175°-180° C.
後処理
- temperatureAfter refluxing the solution four hours, it
- customThe solvent was removed under reduced pressure
- customThen, the residue was triturated with hexane
出典と根拠
- ORDレコード
- ord-c4cba277fb39411eaa517b4dca1a2955
- 出典データセット
- uspto-grants-1986_09
- 特許番号
- US04609397
反応ノート
読み込み中…