Hydrochloric Acid → HCID 178430834、化合物

HRID 645693ノート

反応式

HRID 645693 の反応式
CO[CH:3](OC)[CH:4](Cl)[CH3:5].Cl.CC([O-])=O.[Na+].[NH2:15][C:16]1[NH:21][C:20](=[O:22])[NH:19][C:18](=[O:23])[CH:17]=1>O>[CH3:5][C:4]1[C:17]2[C:18]([OH:23])=[N:19][C:20]([OH:22])=[N:21][C:16]=2[NH:15][CH:3]=1

参加物

6

反応物 4

HCID 313Hydrochloric Acid2 回HCID 701206-AminouracilHCID 517045Sodium Acetate2 回HCID 51528542-Chloropropionaldehyde dimethyl acetal

生成物 1

HCID 178430834HCID 178430834、化合物収率 94%

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

反応条件

温度
95 °C

実験手順

To a mixture of 2-chloropropionaldehyde dimethyl acetal (5.84 g, 42.1 mmol) in H2O (26 mL) was added conc. HCl (1 mL). After heating at 95° C. for 15 min (or until the solution turns homogenous), NaOAc (5.2 g) was added to neutralize the excess HCl. The resulting solution was then transferred to a separate flask containing a suspension of 6-aminouracil (4 g, 31.5 mmol) and NaOAc (2.6 g) in H2O (52 mL). After heating the mixture at reflux overnight, the reaction was cooled and the precipitates were collected by filtration to give 5-methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diol (4.8 g, 94% yield).

後処理

  1. additionwas added
  2. customThe resulting solution was then transferred to a separate flask
  3. additioncontaining
  4. temperatureAfter heating the mixture
  5. temperatureat reflux overnight
  6. temperaturethe reaction was cooled
  7. filtrationthe precipitates were collected by filtration

出典と根拠

ORDレコード
ord-a9df538fcb11438db3783aef53306f67
出典データセット
uspto-grants-2010_04
特許番号
US07705004B2

反応ノート

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