Ethyl 5-aminocarbonyl-4,6-diethoxy-2-(trifluoromethyl)-3-pyridinecarboxylate → Ethyl 5-cyano-4,6-diethoxy-2-(trifluoromethyl)-3-pyridinecarboxylate
反応式
[NH2:1][C:2]([C:4]1[C:5]([O:22][CH2:23][CH3:24])=[C:6]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[C:7]([C:13]([F:16])([F:15])[F:14])=[N:8][C:9]=1[O:10][CH2:11][CH3:12])=O>O=P(Cl)(Cl)Cl>[C:2]([C:4]1[C:5]([O:22][CH2:23][CH3:24])=[C:6]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[C:7]([C:13]([F:16])([F:14])[F:15])=[N:8][C:9]=1[O:10][CH2:11][CH3:12])#[N:1]参加物
3
実験手順
A mixture of 6.17 g (0.018 mol) of product of Example 23 and 100 ml of POCl3 was held at reflux for 7 hours and concentrated in vacuo. The residue was poured into water and extracted with ether. The ether extract was washed with 15% K2CO3, dried (MgSO4) and concentrated to give 1.44 g (24.6%) of product as an oil; nD25 1.4677.