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HRID 645733作成日：2026年10月26日

Phosgene → 4,5-Bis-(4-chloro-phenyl)-2-(2,4-diethoxy-pyrimidin-5-yl)-4,5-dihydro-imidazole-1-carbonyl chloride

https://huagongshe.com/reaction/645733

反応式

関与物質

役割名称HCID仕込み量
反応物PhosgeneHCID 6371—
反応物4,5-bis-(4-chloro-phenyl)-2-(2,4-diethoxy-pyrimidin-5-yl)-4,5-dihydro-1H-imidazoleHCID 86613627—
生成物4,5-Bis-(4-chloro-phenyl)-2-(2,4-diethoxy-pyrimidin-5-yl)-4,5-dihydro-imidazole-1-carbonyl chlorideHCID 86613626—

反応手順

Using the procedure as described in example 1, cis-4-[4,5-bis-(4-chloro-phenyl)-2-(2,4-diethoxy-pyrimidin-5-yl)-4,5-dihydro-1H-imidazole was reacted with phosgene to give cis-4-[4,5-bis-(4-chloro-phenyl)-2-(2,4-diethoxy-pyrimidin-5-yl)-4,5-dihydro-imidazole-1-carbonyl chloride. The carbonyl chloride was then coupled with 2-piperazinone (Alfa) to give cis-4-[4,5-bis-(4-chloro-phenyl)-2-(2,4-diethoxy-pyrimidin-5-yl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one. HR-MS (ES, m/z) calculated for C28H29N6O4Cl2 [(M+H)+] 583.1622, observed 583.1621.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07705007B2
出典データセットuspto-grants-2010_04
ORD IDord-7dc1c6474a374b829a2d02cf48a344b4
出典メモuspto-grants-2010_04