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HRID 645747作成日：2026年10月27日

N,N-dimethyl-2-(piperazin-1-yl)acetamide → cis-2-{4-[2-(2-tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N,N-dimethyl-acetamide hydrochloride

https://huagongshe.com/reaction/645747

反応式

関与物質

役割名称HCID仕込み量
反応物N,N-dimethyl-2-(piperazin-1-yl)acetamideHCID 2758642—
反応物2-(2-Tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chlorideHCID 86613632—
生成物cis-2-{4-[2-(2-tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N,N-dimethyl-acetamide hydrochlorideHCID 68579294—

反応手順

cis-4-[2-(2-tert-Butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 20) was reacted with N,N-dimethyl-2-piperazin-1-yl-acetamide (Oakwood Products) to give cis-2-{4-[2-(2-tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N,N-dimethyl-acetamide hydrochloride in an analogous manner as described in example 1. HR-MS (ES, m/z) calculated for C34H42N7O3Cl2 [(M+H)+] 666.2721, observed 666.2721.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07705007B2
出典データセットuspto-grants-2010_04
ORD IDord-dda86457f9f140d296cd0564ac926707
出典メモuspto-grants-2010_04