1-(Morpholinocarbonylmethyl)piperazine → cis-2-{4-[2-(2-Tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-1-morpholin-4-yl-ethanone

関与物質

役割	名称	HCID	仕込み量
反応物	1-(Morpholinocarbonylmethyl)piperazine	HCID 100622	—
反応物	2-(2-Tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride	HCID 86613632	—
生成物	cis-2-{4-[2-(2-Tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-1-morpholin-4-yl-ethanone	HCID 24775245	—

反応手順

cis-4-[2-(2-tert-Butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 20) was reacted with 1-morpholin-4-yl-2-piperazin-1-yl-ethanone (Oakwood Products) to give cis-2-{4-[2-(2-tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-1-morpholin-4-yl-ethanone in an analogous manner as described in example 1. HR-MS (ES, m/z) calculated for C36H44N7O4Cl2 [(M+H)+] 708.2827, observed 708.2830.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07705007B2
出典データセット	uspto-grants-2010_04
ORD ID	ord-46fa47e591444c2ca465f9f911065e98
出典メモ	uspto-grants-2010_04