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tert-Butyl piperazine-1-carboxylate → 1-(3-(Methylsulfonyl)propyl)piperazine dihydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| 反応物 | 3-(Methylsulfonyl)propyl methanesulfonate | HCID 10262758 | — |
| 反応物 | N-(2-methoxy-1-methylethyl)-2-piperazin-1-yl-acetamide dihydrochloride | HCID 67245894 | — |
| 生成物 | 1-(3-(Methylsulfonyl)propyl)piperazine dihydrochloride | HCID 49853479 | — |
反応手順
1-(3-Methanesulfonyl-propyl)-piperazine dihydrochloride was prepared from 1-tert-butyloxycarbonyl-piperazine and methanesulfonic acid 3-methanesulfonyl-propyl ester (prepared according to Baerlocher, F. J. et al. Aust. J. Chem. 1999, 52, 167-172) in an analogous manner as described for the preparation of N-(2-methoxy-1-methyl-ethyl)-2-piperazin-1-yl-acetamide dihydrochloride (example 40).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07705007B2 |
| 出典データセット | uspto-grants-2010_04 |
| ORD ID | ord-2d00d5a416a84e138dbe3dd3a13d688f |
| 出典メモ | uspto-grants-2010_04 |