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HRID 645755作成日：2026年10月27日

1-(3-(Methylsulfonyl)propyl)piperazine dihydrochloride → cis-[2-(2-Tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazol-1-yl]-[4-(3-methanesulfonyl-propyl)-piperazin-1-yl]-methanone

https://huagongshe.com/reaction/645755

反応式

関与物質

役割名称HCID仕込み量
反応物1-(3-(Methylsulfonyl)propyl)piperazine dihydrochlorideHCID 49853479—
反応物2-(2-Tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chlorideHCID 86613632—
生成物cis-[2-(2-Tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazol-1-yl]-[4-(3-methanesulfonyl-propyl)-piperazin-1-yl]-methanoneHCID 24775346—

反応手順

cis-4-[2-(2-tert-Butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 20) was reacted with 1-(3-methanesulfonyl-propyl)-piperazine dihydrochloride to give cis-[2-(2-tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazol-1-yl]-[4-(3-methanesulfonyl-propyl)-piperazin-1-yl]-methanone in an analogous manner as described in example 1. HR-MS (ES, m/z) calculated for C34H43N6O4SCl2 [(M+H)+] 701.2438, observed 701.2439.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07705007B2
出典データセットuspto-grants-2010_04
ORD IDord-6b63cc057b01400f92c3376302875349
出典メモuspto-grants-2010_04