Potassium Hydroxide → 2-{4-[(Quinoxalin-2-yl)oxy]phenoxy}propanoic acid

HRID 64576

反応式

HRID 64576 の反応式
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[CH:3][C:2]=1[O:11][C:12]1[CH:24]=[CH:23][C:15]([O:16][CH:17]([CH3:22])[C:18]([O:20]C)=[O:19])=[CH:14][CH:13]=1.[OH-].[K+]>O.CO>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[CH:3][C:2]=1[O:11][C:12]1[CH:13]=[CH:14][C:15]([O:16][CH:17]([CH3:22])[C:18]([OH:20])=[O:19])=[CH:23][CH:24]=1

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 187099Methyl 2-(4-(2-quinoxalinyloxy)phenoxy)propanoate

生成物 1

HCID 136705312-{4-[(Quinoxalin-2-yl)oxy]phenoxy}propanoic acid

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

3.2 g (0.01 mole) Methyl 2-[4-(2-quinoxalinyloxy)phenoxy]propanoate was added to a solution of 0.7 g (0.01 mole) potassium hydroxide in 5 cc water and 60 cc methanol. The mixture was stirred at room temperature overnight and then filtered to remove a small amount of insoluble material. The methanol was removed under vacuum. Ice and hydrochloric acid were added to the mixture until it was acidic (pH~2). The precipitated acid was filtered and purified by redissolution into saturated sodium bicarbonate solution, reprecipitation by acidification with dilute hydrochloric acid and crystallization from methanol. Yield 0.7 g, m.p. 137°-141°.

後処理

  1. filtrationfiltered
  2. customto remove a small amount of insoluble material
  3. customThe methanol was removed under vacuum
  4. additionIce and hydrochloric acid were added to the mixture until it
  5. filtrationThe precipitated acid was filtered
  6. custompurified by redissolution into saturated sodium bicarbonate solution, reprecipitation by acidification with dilute hydrochloric acid and crystallization from methanol

出典と根拠

ORDレコード
ord-ac1ce241150440a9bab18cfbd19acab5
出典データセット
uspto-grants-1986_09
特許番号
US04609396

関連ノート

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