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HRID 645764作成日：2026年10月27日

N,N-Bis-(2-methoxy-ethyl)-2-piperazin-1-yl-acetamide dihydrochloride → 2-(4-[(4S,5R)-4,5-bis-(4-chloro-phenyl)-2-(3-ethoxy-thiophen-2-yl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N,N-bis-(2-methoxy-ethyl)-acetamide

https://huagongshe.com/reaction/645764

反応式

関与物質

役割名称HCID仕込み量
反応物N,N-Bis-(2-methoxy-ethyl)-2-piperazin-1-yl-acetamide dihydrochlorideHCID 67246429—
反応物cis-4,5-Bis-(4-chloro-phenyl)-2-(3-ethoxy-thiophen-2-yl)-4,5-dihydro-imidazole-1-carbonyl chlorideHCID 86613636—
生成物2-(4-[(4S,5R)-4,5-bis-(4-chloro-phenyl)-2-(3-ethoxy-thiophen-2-yl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N,N-bis-(2-methoxy-ethyl)-acetamideHCID 24775527—

反応手順

2-{4-[(4S,5R)-4,5-Bis-(4-chloro-phenyl)-2-(3-ethoxy-thiophen-2-yl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 34) was reacted with N,N-bis-(2-methoxy-ethyl)-2-piperazin-1-yl-acetamide dihydrochloride to give 2-(4-[(4S,5R)-4,5-bis-(4-chloro-phenyl)-2-(3-ethoxy-thiophen-2-yl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N,N-bis-(2-methoxy-ethyl)-acetamide in an analogous manner as described in example 1. LR-MS: 702.3 [(M+H)+]

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07705007B2
出典データセットuspto-grants-2010_04
ORD IDord-0485a562b9ea4252b9817229b2604aa9
出典メモuspto-grants-2010_04