戻る
化工社化工社 化学情報印刷レポート · 研究参考用
HRID 645766作成日：2026年10月27日

cis-4,5-Bis-(4-chloro-phenyl)-2-(3-ethoxy-thiophen-2-yl)-4,5-dihydro-imidazole-1-carbonyl chloride → 2-{4-[(4S,5R)-4,5-bis-(4-chloro-phenyl)-2-(3-ethoxy-thiophen-2-yl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N-methoxy-N-methyl-acetamide

https://huagongshe.com/reaction/645766

反応式

関与物質

役割名称HCID仕込み量
反応物cis-4,5-Bis-(4-chloro-phenyl)-2-(3-ethoxy-thiophen-2-yl)-4,5-dihydro-imidazole-1-carbonyl chlorideHCID 86613636—
反応物N-methoxy-N-methyl-2-piperazin-1-yl-acetamide dihydrochlorideHCID 86613637—
生成物2-{4-[(4S,5R)-4,5-bis-(4-chloro-phenyl)-2-(3-ethoxy-thiophen-2-yl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N-methoxy-N-methyl-acetamideHCID 24775528—

反応手順

2-{4-[(4S,5R)-4,5-Bis-(4-chloro-phenyl)-2-(3-ethoxy-thiophen-2-yl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 34) was reacted with N-methoxy-N-methyl-2-piperazin-1-yl-acetamide dihydrochloride to give 2-{4-[(4S,5R)-4,5-bis-(4-chloro-phenyl)-2-(3-ethoxy-thiophen-2-yl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N-methoxy-N-methyl-acetamide in an analogous manner as described in example 1. LR-MS: 630.3 [(M+H)+].

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07705007B2
出典データセットuspto-grants-2010_04
ORD IDord-08f869df0c9f44989fc27b5992644c27
出典メモuspto-grants-2010_04