Diethylamine → N,N-diethyl-2-[4-(quinoxalinyloxy)phenoxy]propanamide

HRID 64578

反応式

HRID 64578 の反応式
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[CH:3][C:2]=1[O:11][C:12]1[CH:23]=[CH:22][C:15]([O:16][CH:17]([CH3:21])[C:18](Cl)=[O:19])=[CH:14][CH:13]=1.[CH2:24]([NH:26][CH2:27][CH3:28])[CH3:25]>C(Cl)Cl>[CH2:24]([N:26]([CH2:27][CH3:28])[C:18](=[O:19])[CH:17]([O:16][C:15]1[CH:22]=[CH:23][C:12]([O:11][C:2]2[CH:3]=[N:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[N:1]=2)=[CH:13][CH:14]=1)[CH3:21])[CH3:25]

参加物

4

反応物 2

HCID 8021DiethylamineHCID 136705322-[4-(2-Quinoxalinyloxy)phenoxy]propionyl chloride

生成物 1

HCID 13670533N,N-diethyl-2-[4-(quinoxalinyloxy)phenoxy]propanamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

The title compound can be prepared by interaction of 2-[4-(2-quinoxalinyloxy)phenoxy]propionic acid with thionyl chloride in a suitable solvent such as chlorobutane. Add a solution of 3.3 g (0.01 mole) 2-[4-(2-quinoxalinyloxy)phenoxy]propionyl chloride in 30 cc methylene chloride to a cold (5° C.) solution of 1.8 g (0.025 mole) diethylamine in 30 cc methylene chloride. Stir the mixture at room temperature overnight. Wash the methylene chloride solution with water and dry over magnesium sulfate. Remove the methylene chloride under vacuum to yield N,N-diethyl-2-[4-(quinoxalinyloxy)phenoxy]propanamide.

後処理

  1. washWash the methylene chloride solution with water
  2. dry with materialdry over magnesium sulfate
  3. customRemove the methylene chloride under vacuum

出典と根拠

ORDレコード
ord-7b160d66813745f18aafc58f5939045e
出典データセット
uspto-grants-1986_09
特許番号
US04609396

関連ノート

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