Water → 2-(4-Hydroxyphenoxy)-3-methylquinoxaline

HRID 64582

反応式

HRID 64582 の反応式
C([O:8][C:9]1[CH:26]=[CH:25][C:12]([O:13][C:14]2[C:23]([CH3:24])=[N:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[N:15]=2)=[CH:11][CH:10]=1)C1C=CC=CC=1.O>C(Cl)Cl>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([O:13][C:14]2[C:23]([CH3:24])=[N:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[N:15]=2)=[CH:25][CH:26]=1

参加物

4

反応物 2

HCID 962WaterHCID 136705372-(4-Benzyloxyphenoxy)-3-methylquinoxaline

生成物 1

HCID 136705382-(4-Hydroxyphenoxy)-3-methylquinoxaline収率 50.7%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒3 回

実験手順

A solution of 12.5 g (0.05 mole) borontribromide in 100 cc methylene chloride was added, over a period of 40 minutes, to a well stirred, cold (-62° C.) solution of 17.1 g 2-(4-benzyloxyphenoxy)-3-methylquinoxaline (0.05 mole) in 400 cc methylene chloride. When the addition was complete, the temperature of the reaction was allowed to rise slowly (2 hours) to room temperature. The reaction mixture was then poured into 1 liter of water and an additional 500 cc of methylene chloride was added. The mixture was stirred vigorously for 40 minutes and the insoluble solid was filtered. Crystallization from an ethanol-water mixture (1:1) gave 6.4 g of product, m.p. 175°-178° C.

後処理

  1. additionWhen the addition
  2. custom(2 hours)
  3. customto room temperature
  4. stirringThe mixture was stirred vigorously for 40 minutes
  5. filtrationthe insoluble solid was filtered
  6. customCrystallization from an ethanol-water mixture (1:1)

出典と根拠

ORDレコード
ord-2e50a64fef51404880287fa09ec46d4f
出典データセット
uspto-grants-1986_09
特許番号
US04609396

関連ノート

読み込み中…