関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | Monobenzone | HCID 7638 | — |
| 反応物 | Methyl 2-bromopropionate | HCID 95576 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Methyl 2-[p-(benzyloxy)phenoxy]propionate | HCID 13093988 | — |
反応手順
A 42 g (0.25 mole) portion of methyl 2-bromopropionate was added to 0.25 mole of the sodium salt of p-benzyloxyphenol (prepared from 13.5 g sodium methoxide and 50 g p-benzyloxyphenoxy) in 70 cc of DMF. The reaction mixture was heated at approximately 80° C. for 14.5 hours. The cooled reaction mixture was then poured into 1 liter ice-water. The product was isolated by ether extraction and was crystallized from methanol to give 45.2 g methyl 2-(4-benzyloxyphenoxy)propanoate, m.p. 38°-42°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04609396 |
|---|
| 出典データセット | uspto-grants-1986_09 |
|---|
| ORD ID | ord-66bb2d2a00534e9c92b4ff15626c6f80 |
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| 出典メモ | uspto-grants-1986_09 |
|---|
