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Hydroxyamine hydrochloride → 6-Methyl-1H-indole-3-carbaldehyde oxime
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 反応物 | Sodium Acetate | HCID 517045 | — |
| 反応物 | 6-Methylindole-3-carboxaldehyde | HCID 4777902 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 6-Methyl-1H-indole-3-carbaldehyde oxime | HCID 136395569 | 91.4% |
反応手順
To a solution of 6-methyl-1H-indole-3-carbaldehyde (0.96 g, Lit. 5) in ethanol (30 ml) was added at 22° C. hydroxylamine hydrochloride (0.46 g) and sodium acetate (0.54 g) and the mixture was stirred for 3 h. The mixture was evaporated and the residue triturated with water and dichloromethane/n-heptane (1:1) and dried to give 6-methyl-1H-indole-3-carbaldehyde oxime (0.96 g) as a pink solid. MS: 175.3 ([M+H]+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07705034B2 |
| 出典データセット | uspto-grants-2010_04 |
| ORD ID | ord-b90193e147e7431d8791c9d28d336624 |
| 出典メモ | uspto-grants-2010_04 |