Benzaldehyde → (5-Fluoro-3-methyl-benzo[b]thiophen-2-yl)-phenyl-methanol

反応式

[F:1][C:2]1[CH:11]=[CH:10][C:5]2[S:6][CH:7]=[C:8]([CH3:9])[C:4]=2[CH:3]=1.[CH:12](=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[F:1][C:2]1[CH:11]=[CH:10][C:5]2[S:6][C:7]([CH:12]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[OH:19])=[C:8]([CH3:9])[C:4]=2[CH:3]=1

参加物

反応物 2

HCID 240Benzaldehyde

HCID 5968285-Fluoro-3-methyl-benzo[b]thiophene

生成物 1

HCID 68579253(5-Fluoro-3-methyl-benzo[b]thiophen-2-yl)-phenyl-methanol

実験手順

Using general procedure B, 5-fluoro-3-methyl-benzo[b]thiophene was reacted with benzaldehyde to give (5-fluoro-3-methyl-benzo[b]thiophen-2-yl)-phenyl-methanol as a pale yellow oil. MS: 255.3 ([M+H—H2O]+).

出典と根拠

ORDレコード: ord-c171a1e4b15c404a9ed21fce6b0dba1f
出典データセット: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07705034B2

反応ノート

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