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Triethylamine → 3-[(3-Nitro-2-pyrazinyl)amino]-1,2-propanediol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 3-Amino-1,2-propanediol | HCID 73561 | — |
| 反応物 | 2-Chloro-3-nitropyrazine | HCID 15914235 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 3-[(3-Nitro-2-pyrazinyl)amino]-1,2-propanediol | HCID 15914239 | — |
反応手順
To a solution of 1.5 g (0.0094 mol) 3 and 1.01 g (0.01 mol) triethylamine in 25 ml isopropanol is added 0.91 g (0.01 mol) 3-amino-1,2-propanediol (10). The reaction mixture becomes reddish and is stirred at room temperature for 16 hours. The solvent is then removed on the rotary evaporator and the residue is purified by flash chromatography on silica gel to afford pure 11 as a yellow solid, m.p. 100°-102°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04609659 |
| 出典データセット | uspto-grants-1986_09 |
| ORD ID | ord-823de0febb72478ca27925ee6def8ecd |
| 出典メモ | uspto-grants-1986_09 |