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Triethylamine → 2-(2,3-Dihydroxypropyl)amino-5-nitropyrazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 3-Amino-1,2-propanediol | HCID 73561 | — |
| 反応物 | 2-Chloro-5-nitropyrazine | HCID 1502058 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 2-(2,3-Dihydroxypropyl)amino-5-nitropyrazine | HCID 15914240 | — |
反応手順
To a solution of 0.5 g (0.003 mol) 6 and 0.3 g (0.003 mol) triethylamine in 10 ml acetonitrile is added 0.32 g (0.0035 mol) 3-amino-1,2-propanediol (10) in 10 ml iso-propanol. After stirring for 18 hours at room temperature the solvent is removed on the rotary evaporator and the residue is purified by flash chromatography on silica gel eluting with 10% methanol/chloroform. Pure 12 has Rf 0.4 and is a pale yellow solid, m.p. 185°-7°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04609659 |
| 出典データセット | uspto-grants-1986_09 |
| ORD ID | ord-9189957e7c0046d48e53693f5f293595 |
| 出典メモ | uspto-grants-1986_09 |