Bromocyclopentane → 5-Bromo-2-(cyclopentyloxy)pyridine
反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5](=[O:8])[NH:6][CH:7]=1.[CH:9]1(Br)[CH2:13][CH2:12][CH2:11][CH2:10]1>C1(C)C=CC=CC=1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][CH:9]2[CH2:13][CH2:12][CH2:11][CH2:10]2)=[N:6][CH:7]=1参加物
4
反応条件
- 温度
- 60 °C
実験手順
A mixture of 5-bromo-1H-pyridin-2-one (4.0 g, 23 mmol), Ag2CO3 (3.77 g, 1.37 mmol), cyclopentyl bromide (7.4 mL, 29 mmol) and toluene (30 ml) was stirred at 60° C. for 2 days. The reaction was filtered through Celite® and the filter cake was washed with EtOAc. Concentration and vacuum distillation gave the sub-title compound (5.09 g, 92%).
後処理
- filtrationThe reaction was filtered through Celite®
- washthe filter cake was washed with EtOAc
- concentrationConcentration and vacuum distillation
出典と根拠
- ORDレコード
- ord-85f247926378474c8a0c87b198e15122
- 出典データセット
- uspto-grants-2010_04
- 特許番号
- US07705023B2
反応ノート
読み込み中…