Ethyl 5-Bromoindole-2-carboxylate → 5-Bromo-1-(4-cyclopentoxyphenyl)-1H-indole-2-carboxylic acid ethyl ester

反応式

[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([Br:15])=[CH:10][CH:9]=2)=[O:5])[CH3:2].[CH:16]1([O:21][C:22]2[CH:27]=[CH:26][C:25](B(O)O)=[CH:24][CH:23]=2)[CH2:20][CH2:19][CH2:18][CH2:17]1>>[CH2:1]([O:3][C:4]([C:6]1[N:7]([C:25]2[CH:26]=[CH:27][C:22]([O:21][CH:16]3[CH2:20][CH2:19][CH2:18][CH2:17]3)=[CH:23][CH:24]=2)[C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([Br:15])=[CH:10][CH:9]=2)=[O:5])[CH3:2]

参加物

反応物 2

HCID 259091Ethyl 5-Bromoindole-2-carboxylate

HCID 23005412(4-(Cyclopentyloxy)phenyl)boronic acid

生成物 1

HCID 686965745-Bromo-1-(4-cyclopentoxyphenyl)-1H-indole-2-carboxylic acid ethyl ester

実験手順

The sub-title compound was prepared in accordance with Example 8(c), using 5-bromo-1H-indole-2-carboxylic acid ethyl ester and 4-cyclopentoxy-phenylboronic acid (see step (b) above).

出典と根拠

ORDレコード: ord-8f914342e46a42e98207a1f3cd287e8c
出典データセット: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07705023B2

反応ノート

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