Pyrrole-2-carboxaldehyde → HCID 11564718、化合物

HRID 646185ノート

反応式

HRID 646185 の反応式
[NH:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]=O.[CH3:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH2:15][C:16]#[N:17]>C(O)C>[CH3:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1/[C:15](=[CH:6]/[C:2]1[NH:1][CH:5]=[CH:4][CH:3]=1)/[C:16]#[N:17]

参加物

4

反応物 2

HCID 13854Pyrrole-2-carboxaldehydeHCID 311552-(o-Tolyl)acetonitrile

生成物 1

HCID 11564718HCID 11564718、化合物収率 30.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
90 °C

実験手順

A thick walled tube was charged with 1H-pyrrole-2-carbaldehyde (2.0 g, 21.0 mmol), 2-methylphenylacetonitrile (2.5 g, 18.9 mmol, 0.9 equivalents), ethanol (75 ml), and 40% aqueous Triton B (4.0 ml, 3.3 mmol). The tube was sealed and heated to 90° C. for 4 days. Removal of the solvent, followed by chromatography on silica gel using dichloromethane/petroleum spirits (20:80) as eluant afforded a yellow solid (1.2 g). This is Compound 16 in Table 8.

後処理

  1. customThe tube was sealed
  2. customRemoval of the solvent

出典と根拠

ORDレコード
ord-f0f6894a5e0e45489252798d02e21b8b
出典データセット
uspto-grants-2010_04
特許番号
US07705038B2

反応ノート

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