Water → 4-[(2,4-Dichlorophenyl)phenylmethyl]-1H-pyrazole

HRID 64633ノート

反応式

HRID 64633 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]([CH:16]([CH:19]=O)[CH:17]=O)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[NH2:21][NH2:22].O>C(O)C>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:16]1[CH:19]=[N:21][NH:22][CH:17]=1

参加物

5

反応物 3

HCID 962WaterHCID 9321HydrazineHCID 54388185HCID 54388185、化合物

生成物 1

HCID 136726874-[(2,4-Dichlorophenyl)phenylmethyl]-1H-pyrazole

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Two grams of [(2,4-dichlorophenyl)phenylmethyl]malonaldehyde in 10 ml of ethanol were heated with 3 ml of anhydrous hydrazine on a steam bath for two hours. The reaction mixture was poured into water and extracted with ether. The ether extract was dried, filtered, and evaporated. The residue was crystallized twice from Skelley B/acetone to provide 1.2 g of the desired title product, m.p. 131° C.

後処理

  1. extractionextracted with ether
  2. extractionThe ether extract
  3. customwas dried
  4. filtrationfiltered
  5. customevaporated
  6. customThe residue was crystallized twice from Skelley B/acetone

出典と根拠

ORDレコード
ord-cb337b6c2bb44925af26f18ccc8fd109
出典データセット
uspto-grants-1986_09
特許番号
US04609666

反応ノート

読み込み中…