(S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidine → (2(S)-Pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-(6-thiophen-2-yl-pyridin-3-yl)-methanone

HRID 646428

反応式

HRID 646428 の反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:14]=[CH:13][C:9]([C:10]([OH:12])=O)=[CH:8][N:7]=1.[NH:15]1[CH2:19][CH2:18][CH2:17][C@H:16]1[CH2:20][N:21]1[CH2:25][CH2:24][CH2:23][CH2:22]1>>[N:21]1([CH2:20][C@@H:16]2[CH2:17][CH2:18][CH2:19][N:15]2[C:10]([C:9]2[CH:8]=[N:7][C:6]([C:2]3[S:1][CH:5]=[CH:4][CH:3]=3)=[CH:14][CH:13]=2)=[O:12])[CH2:25][CH2:24][CH2:23][CH2:22]1

参加物

3

反応物 2

HCID 853152(S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidineHCID 154111446-(Thiophen-2-Yl)Pyridine-3-Carboxylic Acid

生成物 1

HCID 11508383(2(S)-Pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-(6-thiophen-2-yl-pyridin-3-yl)-methanone

実験手順

The title compound is prepared in a manner substantially analogous to General Procedure D using 6-thiophen-2-yl-nicotinic acid (CAS 179408-54-9) and (S)(+)-1-(2-pyrrolidinylmethyl)pyrrolidine to give the title compound (58 mg). MS (ES+) 342.1 (M+H)+

後処理

  1. customThe title compound is prepared in a manner substantially analogous to General Procedure D

出典と根拠

ORDレコード
ord-5b3d7a16dfeb4276b105e2cd2a7d2507
出典データセット
uspto-grants-2010_04
特許番号
US07705025B2

関連ノート

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