Ethylamine → 5-(2,4-Bis-benzyloxy-5-bromophenyl)-isoxazole-3-carboxylic acid ethylamide

HRID 646487ノート

反応式

HRID 646487 の反応式
C([O:3][C:4]([C:6]1[CH:10]=[C:9]([C:11]2[CH:16]=[C:15]([Br:17])[C:14]([O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[CH:13][C:12]=2[O:26][CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[O:8][N:7]=1)=O)C.[CH2:34]([NH2:36])[CH3:35]>C(O)C>[CH2:34]([NH:36][C:4]([C:6]1[CH:10]=[C:9]([C:11]2[CH:16]=[C:15]([Br:17])[C:14]([O:18][CH2:19][C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)=[CH:13][C:12]=2[O:26][CH2:27][C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)[O:8][N:7]=1)=[O:3])[CH3:35]

参加物

4

反応物 2

HCID 6341EthylamineHCID 247745225-(2,4-Bis-benzyloxy-5-bromo-phenyl)-isoxazole-3-carboxylic acid ethyl ester

生成物 1

HCID 247745235-(2,4-Bis-benzyloxy-5-bromophenyl)-isoxazole-3-carboxylic acid ethylamide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

5-(2,4-bis-benzyloxy-5-bromo-phenyl)-isoxazole-3-carboxylic acid ethyl ester was suspended in ethanol and ethylamine (2M in methanol, 3 eq), the resulting yellow suspension was heated to reflux (80° C.) under nitrogen, at which point the reagents went into solution. This was heated for 14 hours, then left to cool to ambient temperature. A white precipitate formed, which was filtered off and washed with further ethanol before being dried in vacuo.

後処理

  1. temperatureThis was heated for 14 hours
  2. waitleft
  3. temperatureto cool to ambient temperature
  4. customA white precipitate formed
  5. filtrationwhich was filtered off
  6. washwashed with further ethanol
  7. custombefore being dried in vacuo

出典と根拠

ORDレコード
ord-964687924e934610adb3849f6cee7be9
出典データセット
uspto-grants-2010_04
特許番号
US07705027B2

反応ノート

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