Chlorine → 2-Chloro-4-(trifluoromethoxy)phenol

Gaseous chlorine was slowly introduced to a stirred solution of 35.6 g of 4-trifluoromethoxyphenol in 100 ml carbon tetrachloride. The reaction temperature was kept at 20° to 30° C. by outer cooling. After saturaring with chlorine, the reaction mixture was stirred at 20° to 30° C. for 1 hour, cooled, washed with water, dried over anhydrous sodium sulfate, and evaporated to give a pale yellow residue. The residue was distilled under reduced pressure to give 29.8 g of 2-chloro-4-trifluoromethoxyphenol which boiled at 67°-70° C./18 mmHg.

1. customwas kept at 20° to 30° C. by outer cooling
2. temperaturecooled
3. washwashed with water
4. dry with materialdried over anhydrous sodium sulfate
5. customevaporated
6. customto give a pale yellow residue
7. distillationThe residue was distilled under reduced pressure

ORDレコード

ord-e29a4776f309479c9773dc81cfc33bef

出典データセット

uspto-grants-1986_09

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US04609669