Resorcinol → 1-(2,4-Dihydroxyphenyl)-2-methylpropan-1-one

HRID 646509ノート

反応式

HRID 646509 の反応式
[C:1]1([CH:8]=[CH:7][CH:6]=[C:4]([OH:5])[CH:3]=1)[OH:2].B(F)(F)F.CCOCC.[C:18](O)(=[O:22])[CH:19]([CH3:21])[CH3:20].CC([O-])=O.[Na+]>>[OH:2][C:1]1[CH:3]=[C:4]([OH:5])[CH:6]=[CH:7][C:8]=1[C:18](=[O:22])[CH:19]([CH3:21])[CH3:20]

参加物

5

反応物 4

HCID 5054ResorcinolHCID 6590Isobutyric AcidHCID 8000Boron trifluoride etherateHCID 517045Sodium Acetate

生成物 1

HCID 159157311-(2,4-Dihydroxyphenyl)-2-methylpropan-1-one

反応条件

温度
90 °C

実験手順

Resorcinol (1 eq) was taken up in BF3.OEt2 (6 eq) and isobutyric acid (1 eq) added. The solution was heated for 1.5 hours at 90° C. than allowed to cool to room temperature. The solution was added drop wise to 10% NaOAc (aq) and allowed to stand for 4 hours, before being extracted in to EtOAc. The organic phases were combined and washed with sat. NaHCO3 (aq), then dried over magnesium sulfate, filtered and concentrated in vacuo to give 1-(2,4-dihydroxy-phenyl)-2-methyl-propan-1-one as a red oil which was used without additional purification

後処理

  1. temperatureto cool to room temperature
  2. extractionbefore being extracted in to EtOAc
  3. washwashed with sat. NaHCO3 (aq)
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-629a491d9c504328bf566b1815872bd6
出典データセット
uspto-grants-2010_04
特許番号
US07705027B2

反応ノート

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