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Hydrogen Bromide → 5-Bromo-3-methylpentanoic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrogen Bromide | HCID 260 | — |
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | beta-Methyl-delta-valerolactone | HCID 79142 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 5-Bromo-3-methylpentanoic acid ethyl ester | HCID 13191827 | — |
反応手順
A solution of 16.0 g. (0.14 mol) 4-methyl-3,4,5,6-tetrahydro-2-pyranone in 50 ml. anhydrous ethanol is saturated with hydrogen bromide gas at 0°-5° C., left to stand overnight, poured into water and extracted with diethyl ether. The combined ether extracts are dried over anhydrous sodium sulphate and evaporated and the residue is distilled in a vacuum to give 21.9 g. (70% of theory) of the desired product in the form of a colourless liquid; b.p. 85°-87° C./0.1 mm.; nD20 =1.4590.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04609673 |
| 出典データセット | uspto-grants-1986_09 |
| ORD ID | ord-e193ada018fe4b62b03a9ff0bfef91c2 |
| 出典メモ | uspto-grants-1986_09 |