Hydrogen Bromide → 5-Bromo-3-methylpentanoic acid ethyl ester

HRID 64663

反応式

HRID 64663 の反応式
[CH3:1][CH:2]1[CH2:7][CH2:6][O:5][C:4](=[O:8])[CH2:3]1.[CH2:9](O)[CH3:10].[BrH:12]>O>[CH2:9]([O:5][C:4](=[O:8])[CH2:3][CH:2]([CH3:1])[CH2:7][CH2:6][Br:12])[CH3:10]

参加物

5

反応物 3

HCID 260Hydrogen BromideHCID 702EthanolHCID 79142beta-Methyl-delta-valerolactone

生成物 1

HCID 131918275-Bromo-3-methylpentanoic acid ethyl ester

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 16.0 g. (0.14 mol) 4-methyl-3,4,5,6-tetrahydro-2-pyranone in 50 ml. anhydrous ethanol is saturated with hydrogen bromide gas at 0°-5° C., left to stand overnight, poured into water and extracted with diethyl ether. The combined ether extracts are dried over anhydrous sodium sulphate and evaporated and the residue is distilled in a vacuum to give 21.9 g. (70% of theory) of the desired product in the form of a colourless liquid; b.p. 85°-87° C./0.1 mm.; nD20 =1.4590.

後処理

  1. waitleft
  2. extractionextracted with diethyl ether
  3. dry with materialThe combined ether extracts are dried over anhydrous sodium sulphate
  4. customevaporated
  5. distillationthe residue is distilled in a vacuum
  6. customto give 21.9 g

出典と根拠

ORDレコード
ord-e193ada018fe4b62b03a9ff0bfef91c2
出典データセット
uspto-grants-1986_09
特許番号
US04609673

関連ノート

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