Ganciclovir → Ganciclovir Di-O-acetate

HRID 64671

反応式

HRID 64671 の反応式
[OH:1][CH2:2][CH:3]([O:6][CH2:7][N:8]1[CH:16]=[N:15][C:14]2[C:13](=[O:17])[NH:12][C:11]([NH2:18])=[N:10][C:9]1=2)[CH2:4][OH:5]>CN(C)C1C=CN=CC=1.C(OC(=O)C)(=O)C>[C:2]([O:1][CH2:2][CH:3]([O:6][CH2:7][N:8]1[CH:16]=[N:15][C:14]2[C:13](=[O:17])[NH:12][C:11]([NH2:18])=[N:10][C:9]1=2)[CH2:4][O:5][C:13](=[O:17])[CH3:14])(=[O:1])[CH3:3]

参加物

4

反応物 1

HCID 135398740Ganciclovir

生成物 1

HCID 135459822Ganciclovir Di-O-acetate収率 181.5%

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 7918Acetic Anhydride溶媒

実験手順

A mixture of 3.00 g of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, 300 mg of 4-dimethylaminopyridine, and 100 ml of acetic anhydride was vigorously stirred for 3 days at room temperature. The acetic anhydride was removed by evaporation at reduced pressure and the residue recrystallized from methanol to give 3.62 g of 9-(1,3-diacetyloxy-2-propoxymethyl)guanine, m.p. 237°-239° C.

後処理

  1. customThe acetic anhydride was removed by evaporation at reduced pressure
  2. customthe residue recrystallized from methanol

出典と根拠

ORDレコード
ord-ecab7526a4804b5087d56676e3c0b192
出典データセット
uspto-grants-1986_09
特許番号
US04609661

関連ノート

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