関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Methyl 3-aminopyrazinecarboxylate | HCID 72669 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Aminopyrazine carboxamide | HCID 280292 | 97.7% |
反応手順
A suspension of methyl 3-aminopyrazine-2-carboxylate (5 g, 32.6 mmol) and 150 mL of dry methanol saturated with anhydrous ammonia were heated in an autoclave at 110-115° C. for 24 h. Concentration and filtration afforded 3-aminopyrazine-2-carboxamide (4.4 g, 97.7% yield) as a yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07704995B2 |
|---|
| 出典データセット | uspto-grants-2010_04 |
|---|
| ORD ID | ord-18874ded497546f18a4d5fbaeb33b899 |
|---|
| 出典メモ | uspto-grants-2010_04 |
|---|
