3-(1-oxo-4-carboxybutyl)-N-(3-pyridyl)-indole → 5-[1-(Pyridin-3-yl)-1H-indol-3-yl]pentanoic acid

HRID 64683ノート

反応式

HRID 64683 の反応式
O=[C:2]([C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]([C:18]2[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=2)[CH:10]=1)[CH2:3][CH2:4][CH2:5][C:6]([OH:8])=[O:7]>C(O)(=O)C>[C:6]([CH2:5][CH2:4][CH2:3][CH2:2][C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]([C:18]2[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=2)[CH:10]=1)([OH:8])=[O:7]

参加物

3

反応物 1

HCID 136726973-(1-oxo-4-carboxybutyl)-N-(3-pyridyl)-indole

生成物 1

HCID 134903525-[1-(Pyridin-3-yl)-1H-indol-3-yl]pentanoic acid

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To a solution of 0.5 g of 3-(1-oxo-4-carboxybutyl)-N-(3-pyridyl)-indole in 7.5 ml of glacial acetic acid is added 0.5 g of borane-tert-butylamine complex. The reaction mixture is stirred at room temperature overnight. The reaction mixture is concentrated, the residue is dissolved in 10 ml of 1N sodium hydroxide, water is added to the residue, the pH is adjusted to 5.0 with hydrochloric acid and the product is filtered off and dried to yield 3-(4-carboxybutyl)-N-(3-pyridyl)-indole identical to the compound obtained in Example 3b.

後処理

  1. concentrationThe reaction mixture is concentrated
  2. dissolutionthe residue is dissolved in 10 ml of 1N sodium hydroxide
  3. additionwater is added to the residue
  4. filtrationthe product is filtered off
  5. customdried

出典と根拠

ORDレコード
ord-a7924439a9494912a45e5d106a437e48
出典データセット
uspto-grants-1986_09
特許番号
US04609733

反応ノート

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